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Organized by: Jin Wang, Ken Dill, Michael Douglas, Jose Onuchic
The aim of this workshop is to bring together leading researchers from around the world to discuss current progress in uncovering emergent phenomena and design principles that allow living systems to function, develop and evolve under nonequilibrium conditions. It will be organized to encourage discussion between diverse research communities of fundamental physical, mathematical and biological questions in nonequilibrium dynamics across many spatial and temporal scales. This will be the very first workshop dedicated to nonequilibrium physics and mathematics in biology at the Simons Center. We hope this becomes the Woodstock of Nonequilibrium Physics in Biology.
The topics for the workshop discussions include:
- Search for the possible principles and emergent laws based on nonequilibrium dynamics and thermodynamics for biology.
- The mathematical foundations and underlying geometrical/topological connections behind the nonequilibrium dynamics and thermodynamics as well as the implications to biology.
- How nonequilibrium dynamics and thermodynamics determine the structure, dynamics and functions of the intracellular and intercellular networks.
- How nonequilibrium dynamics and thermodynamics shape the evolution and ecology.
Biology poses challenging questions from the point of view of current physics and mathematics. For example, are there underlying“laws of life”? If so, what are they? If such laws can be found, what is the physics and mathematics behind them? The physicist Schrödinger asked how the creation of order by living things, which must follow physical laws, could be consistent with the Second Law of Thermodynamics. His answer was that living systems can never be in thermodynamic equilibrium and must always exchange material, energy and information with a larger environment. Thus, to quantify a living system requires a nonequilibrium description. While the physics and mathematics of equilibrium systems is well developed, nonequilibrium physics and mathematics remain a fundamental challenge to the physics and mathematics community. In other words, we will need to develop new physics and mathematics to quantify the laws of life.
There has been significant recent progress in the physics and mathematics of nonequilibrium dynamics. Recent work has suggested that the nonequilibrium dynamics is governed by both the underlying landscape and by the steady state probability flux. The flux has a nonconservative (nonzero curl) component which measures the degree of the detailed balance breaking, and quantifies the departure from the equilibrium. On the other hand, the recent developments of nonequilibrium thermodynamics have suggested forms for the thermodynamic driving forces and associated fluctuating statistics for nonequilibrium systems. Interestingly, this recent progress has also suggested geometrical, topological and gauge field descriptions of these driving forces. All of these progresses suggest the possibility of underlying emergent laws. Mutual information optimization and Maximum Caliber have been recently suggested as criteria to test hypotheses about biological function under nonequilibrium conditions against the data. These emergent laws and rich mathematical and physical structures are waiting to be explored.
On the biology front, there are also many challenging questions. These include, how the departure from equilibrium influences cell signaling, gene regulations, epigenetics, the structure and dynamics of intracellular circuitry, cell cycles, cell structures and dynamics, stem cell differentiation and development, neural networks and brain functions, ecology and finally evolution itself, in terms of sensitivity, speed, adaptivity, energy cost, stability, robustness and evolvability. In addition, there are challenging practical questions such as how specific characteristics of the nonequilibrium dynamics of the human body can play a role in diseases such as cancer, aging, immune dysfunction, bacterial infections, Alzheimer’s disease and Parkinson’s disease, etc.
Talk Schedule
Time | Title | Speaker | Location |
8:00am | Breakfast | Simons Center Cafe | |
8:45am | Workshop Begins | N/A | |
9:00am | Folding and protein interactions inside the cell | Martin Gruebele | SCGP 102 |
9:45am | Kinetics and thermodynamics of DNA replication and other molecular information processes | Pierre Gaspard | SCGP 102 |
10:30am | Coffee Break | N/A | N/A |
11:00am | QUANTUM THERMODYNAMICS: From black mold to black holes | Marlan Scully | SCGP 102 |
11:45am | Novel spectroscopic probes of conical intersections, chirality and photosynthetic charge and energy transfer with quantum and x-ray light | Shaul Mukamel | SCGP 102 |
12:30pm | Lunch Break | N/A | Simons Center Cafe |
2:00pm | Non-equilibrium thermodynamics of nanoscale systems | Chris Jarzynski | SCGP 102 |
2:45pm | Experimental Measurement of Information-Content in Mutational Ensembles | Felix Ritort | SCGP 102 |
3:30pm | Coffee Break | N/A | N/A |
4:00pm | Optimal Cellular Information Transmission | Pieter Ten Wolde | SCGP 102 |
4:45pm | Understanding Life One Photon at a Time | Steve Presse | SCGP 102 |
Time | Title | Speaker | Location |
8:00am | Breakfast | Simons Center Cafe | |
8:30am | Maximum Caliber: an inference principle for nonequilibrium statistical mechanics. | Ken Dill | SCGP 102 |
9:15am | Oscillatory enthalpic changes during early embryogenesis driven by the cell cycle | Joe Howard | SCGP 102 |
10:00am | Coffee Break | N/A | N/A |
10:30am | Towards Decoding the Metabolic Plasticity in Cancer: Coupling of Gene Regulation and Metabolic Pathways | Jose Onuchic | SCGP 102 |
11:15am | Quantifying landscape and flux for nonequilibirum biological systems | Jin Wang | SCGP 102 |
12:00pm | Lunch Break | N/A | Simons Center Cafe |
1:00pm | SCGP Weekly Talk – Peter G. Wolynes | N/A | 102 |
2:00pm | Coffee Break | N/A | N/A |
3:00pm | Tissues as Active Systems | Jacques Prost | SCGP 102 |
3:45pm | Exploiting fluctuations to climb gradients faster | Thierry Emonet | SCGP 102 |
Time | Title | Speaker | Location |
8:00am | Breakfast | Simons Center Cafe | |
9:00am | Cellular Pattern Formation via Notch Signaling | Herbert Levine | SCGP 102 |
9:45am | Dynamic instability from non-equilibrium structural transitions on the energy landscape of microtubule | Ao Ma | SCGP 102 |
10:30am | Coffee Break | N/A | N/A |
11:00am | Physical properties of suspensions of active particles | Jean Francois Joanny | SCGP 102 |
11:45am | Accuracy of position determination in Ca$^{2+}$ signaling | Karsten Kruse | SCGP 102 |
12:30pm | Lunch Break | N/A | Simons Center Cafe |
2:00pm | Topology and dynamics in active and living matter | Cristina Marchetti | SCGP 102 |
2:45pm | Theoretical Tool Bridging Cell Polarities with Development of Morphologies | Kim Sneppen | SCGP 102 |
3:30pm | Coffee Break | N/A | N/A |
4:00pm | Affinity maturation of antibodies and the puzzle of HIV low spike density | Mehran Kardar | SCGP 102 |
4:45pm | From caging to super-diffusive behavior in tumor growth | Dave Thirumalai | SCGP 102 |
6:00pm | Conference Dinner | N/A |
Time | Title | Speaker | Location |
8:00am | Breakfast | Simons Center Cafe | |
9:00am | Rama Ranganathan | SCGP 102 | |
9:45am | Bottom-up Assembly of Microbial Communities: Modeling, Analysis and Engineering | Ting Lu | SCGP 102 |
10:30am | Coffee Break | N/A | N/A |
11:00am | Self-Organization and Mechanics in the Cell | Michael Shelley | SCGP 102 |
11:45am | Thermodynamics of open chemical reaction networks: Energy and information transduction in biology | Massimiliano Esposito | SCGP 102 |
12:30pm | Lunch Break | N/A | Simons Center Cafe |
2:00pm | Title:The decision landscapes in living cells | Andre Levchenko | SCGP 102 |
2:45pm | Truth is in the Disorder and Noise | Kingshuk Ghosh | SCGP 102 |
3:30pm | Workshop Discussions | N/A | |
4:30pm | Laufer Center Gathering | N/A |
Time | Title | Speaker | Location |
8:00am | Breakfast | Simons Center Cafe | |
9:00am | The biological catch bond suppresses fluctuations in nonequilibrium systems | Jason Wagoner | SCGP 102 |
9:45am | Coffee Break | N/A | N/A |
10:15am | Emergence of a stable nonequilibrium bacteria-phage collective state from multi-scale feedback | Hong-Yan Shih | SCGP 102 |
12:00pm | Workshop End | N/A |